3-Nitroaniline → HCID 57899406, compound

Participants

Reaction Steps

A solution of amino-cyano-acetic acid ethyl ester (17.06 g, 133.3 mmol) and triethyl orthoformate (19.7 g, 133.3 mmol) in acetonitrile (175 mL) is heated at reflux for 45 min. The reaction mixture is allowed to reach rt and 3-nitro aniline (18.4 g, 133.3 mmol) is added and stirred at rt for 12 h. The crude product obtained is purified by column chromatography to afford the product as pale yellow solid (1).

Provenance & Evidence