反应详情

温度

170 °C

4-Bromo-N-(4-chloro-phenyl)-benzimidoyl chloride is prepared by heating 4-bromo-N-(4-chloro-phenyl)-benzamide (16.5 g, 53.0 mmol) and thionyl chloride (140 mL) for 1 h. The clear solution is concentrated and the residue obtained is coevaporated with toluene (100 mL). Then 5-amino-1-(3-methylsulfanyl-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester (1, 9.8 g, 35.33 mmol) is added and the resulting mixture is heated to 170° C. with out solvent for 6 h. The crude product obtained is purified by column chromatography (6).

1. concentrationThe clear solution is concentrated
2. customthe residue obtained