HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminobenzonitrile → HCID 57899388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminobenzonitrile | HCID 16702 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl 2-amino-2-cyanoacetate | HCID 288716 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 57899388 | HCID 57899388 | — |
Reaction Steps
A solution of amino-cyano-acetic acid ethyl ester (10.6 g, 83.3 mmol) and triethyl orthoformate (12.35 g, 83.3 mmol) in acetonitrile (110 mL) is heated at reflux for 45 min. The reaction mixture is allowed to reach rt and 3-amino-benzonitrile (9.80 g, 83.3 mmol) is added and stirred at rt for 48 h. The crude product obtained is purified by column chromatography (1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722691B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-d8c15f7ac5924e7a86924f440d67312a |
| Source note | uspto-grants-2014_05 |