Potassium Carbonate → HCID 66818891, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (2.09 g, 15.1 mmol) was added to a stirred solution of 2,6-Dichloro-3-nitro pyridine (1.0 g, 5.3 mmol), dissolved in 10 ml of DMF, at a temperature of 5° C. The flask was stirred for 10 min at the same temperature. 4-Cyano phenol (1.26 g, 10.6 mmol), dissolved in 5 ml of DMF was added dropwise to the reaction mixture over a period of 10 min and the flask was heated to 80° C. for 10-12 h. The reaction mixture was poured into ice-cold water and the product was extracted with 250 ml of ethyl acetate. Ethyl acetate layer was washed with water and brine solution. The organic layer was dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 1.35 g of the required 2,6-Bis-(4-cyano phenoxy)-3-nitro pyridine which was used in the next step without further purification. 1H NMR (DMSO-d6): δ 7.06 (1H, d), 7.32 (4H, dd), 7.82 (411, t), 8.74 (1H, d).

Provenance & Evidence