2-Naphthalenesulfonyl chloride → HCID 66818304, compound

HRID 1024674Notes

Reaction equation

HRID 1024674 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[NH2:15][C:16]1[C:17]([O:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]#[N:39])=[CH:34][CH:33]=2)=[N:18][C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=2)=[CH:20][CH:21]=1>>[C:38]([C:35]1[CH:36]=[CH:37][C:32]([O:31][C:17]2[C:16]([NH:15][S:11]([C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[CH:1]=3)(=[O:13])=[O:12])=[CH:21][CH:20]=[C:19]([O:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][CH:24]=3)[N:18]=2)=[CH:33][CH:34]=1)#[N:39]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 66818531HCID 66818531, compound

Product 1

HCID 66818304HCID 66818304, compoundYield 68.5%

Procedure

2-Naphthyl sulfonyl chloride (0.17 g, 0.76 mmol) was added to a stirred solution of 3-amino-2,6-bis(4-cyano phenoxy)pyridine (0.25 g, 0.76 mmol) along with other reagents as mentioned in Example 1(c) to afford 0.27 g of the required product. 1H NMR (DMSO-d6): δ 5.38 (1H, brs), 6.82 (1H, d), 7.12 (1H, d), 7.22 (2H, d), 7.35 (2H, dd), 7.44 (1H, d), 7.80 (7H, m), 7.95 (2H, m), 8.15 (2H, d), 8.56 (1H, s).

Sources & evidence

ORD record
ord-45515a36a8b440c89235f5136e507ad2
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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