HCID 86665952, compound → HCID 49820500, compound

Participants

Reaction Steps

10% Pd/C (0.1 g) was added under an atmosphere of nitrogen gas to 2,6-bis-(4-(N-acetylhydroxycarbamimidoyl)-phenoxy)-3-(4-fluorobenzene-sulphonamido)-pyridine 0.3 g (0.44 mmol) dissolved in 50 ml methanol. 30 mg of 10% Pd/C was added under nitrogen atmosphere and the reaction mixture was stirred under hydrogen pressure (balloon) at room temperature for 3 h. The reaction mixture was passed through celite, washed with methanol and concentrated under reduced pressure. The concentrate was purified using reverse-phase preparative HPLC column to afford 0.06 g. of the required product. Percentage purity (HPLC): 85.01%, (LCMS): 82.73%. 1H NMR (DMSO-d6): 6.75 (2H, d), 6.9 (1H, d), 7.3 (2H, d), 7.5 (2H, d), 7.65 (2H, m), 7.8 (3H, d), 8.0 (4H, m), 8.35 (1H, s), 9.03 (4H, d), 9.2 (4H, s), 10.2 (1H, s).

Provenance & Evidence