3,5-Difluorobenzenesulfonyl chloride → HCID 66818305, compound

HRID 1024678Notes

Reaction equation

HRID 1024678 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][C:14]1[C:15]([O:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]#[N:37])=[CH:32][CH:31]=2)=[N:16][C:17]([O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=2)=[CH:18][CH:19]=1>>[C:36]([C:33]1[CH:34]=[CH:35][C:30]([O:29][C:15]2[C:14]([NH:13][S:9]([C:4]3[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=3)(=[O:11])=[O:10])=[CH:19][CH:18]=[C:17]([O:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=3)[N:16]=2)=[CH:31][CH:32]=1)#[N:37]

Participants

3

Reactant 2

HCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 66818531HCID 66818531, compound

Product 1

HCID 66818305HCID 66818305, compoundYield 75.9%

Procedure

3,5-difluorobenzene sulfonyl chloride (0.5 g, 2.35 mmol) was added to a stirred solution of 3-amino-2,6-bis(4-cyano phenoxy)pyridine (0.77 g, 2.35 mmol) using the reagents and reaction conditions described in Example 1(c) to afford 0.9 g of the required product. 1H NMR (DMSO-d6): δ 6.82 (1H, d), 6.95 (1H, d), 7.11 (2H, d), 7.24 (3H, m), 7.34 (2H, d), 7.80 (7H, m).

Workup

  1. customthe reagents and reaction conditions

Sources & evidence

ORD record
ord-618581825fbb4bd9b98e9d5d59fbe97c
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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