N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → HCID 66818971, compound

HRID 1024689Notes

Reaction equation

HRID 1024689 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14]([C:16]1[CH:46]=[CH:45][C:19]([O:20][C:21]2[N:35]=[C:34]([O:36][C:37]3[CH:42]=[CH:41][C:40]([C:43]#[N:44])=[CH:39][CH:38]=3)[CH:33]=[CH:32][C:22]=2[C:23]([NH:25][CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:24])=[CH:18][CH:17]=1)#[N:15]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][C:11]([N:29]1[CH2:30][CH2:31][CH:26]([NH:25][C:23]([C:22]2[C:21]([O:20][C:19]3[CH:18]=[CH:17][C:16]([C:14]#[N:15])=[CH:46][CH:45]=3)=[N:35][C:34]([O:36][C:37]3[CH:42]=[CH:41][C:40]([C:43]#[N:44])=[CH:39][CH:38]=3)=[CH:33][CH:32]=2)=[O:24])[CH2:27][CH2:28]1)=[O:13])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanineHCID 66818735HCID 66818735, compound

Product 1

HCID 66818971HCID 66818971, compoundYield 81%

Procedure

3-tert-Butoxycarbonylamino-propionic acid (0.177 g, 0.91 mmol) and 2,6-bis-(4-cyano phenoxy)-N-piperidine-4-yl nicotinamide (0.4 g, 0.91 mmol) and other reagents as described in Example 9(e) were used to afford 0.45 g of the required product. Percentage purity (LCMS): 82.8%, (M+1)=610.1+1.

Sources & evidence

ORD record
ord-72bdf6e5a3f14195b70934331080825c
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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