Potassium Carbonate → HCID 66818662, compound

Participants

Reaction Steps

2,6-Bis(4-cyano phenoxy)-N-piperidin-4-yl-isonicotinamide 0.16 g (0.364 mmol), (3-bromo-propyl)-carbamic acid tert-butyl ester 0.12 g (0.50 mmol) and potassium carbonate 0.175 g (1.26 mmol) were used and the procedure of Example 11(e) was followed to afford 0.175 g of the required product. Percentage purity (LCMS): 80.4%, (M+1)=596.2+1. NMR (DMSO-d6): δ 1.40 (9H, s), 1.88 (9H, m), 2.95 (4H, m), 3.85 (2H, m), 6.86 (2H, brs), 7.26 (2H, s), 7.34 (4H, d), 7.85 (4H, d), 8.15 (2H, brs), 9.02 (1H, brs).

Provenance & Evidence