HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenol → 6-(4-Cyanophenoxy)-2-(4-fluorophenoxy)nicotinic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | HCID 86665953 | HCID 86665953 | — |
| Product | 6-(4-Cyanophenoxy)-2-(4-fluorophenoxy)nicotinic acid ethyl ester | HCID 67607700 | 75% |
Reaction Steps
2-Chloro-6-(4-cyano phenoxy)nicotinic acid ethyl ester (0.25 g, 0.81 mmol) and 4-fluorophenol (0.09 g, 0.81 mmol) were coupled using the procedure of Example 17(b) to afford 0.23 g of the required product. Percentage purity (LCMS): 61.86%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722930B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-9b9e8f1a97ad40f69ed234e167c2d297 |
| Source note | uspto-grants-2014_05 |