HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanophenol → 2-(4-Cyanophenoxy)-6-(4-trifluoromethoxyphenoxy)nicotinic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanophenol | HCID 13019 | — |
| Reactant | HCID 86665954 | HCID 86665954 | — |
| Product | 2-(4-Cyanophenoxy)-6-(4-trifluoromethoxyphenoxy)nicotinic acid ethyl ester | HCID 67605757 | 62.4% |
Reaction Steps
2-Chloro-6-(4-trifluoromethoxy phenoxy)nicotinic acid ethyl ester (0.3 g, 0.83 mmol) and 4-cyanophenol (98.8 mg, 0.83 mmol) were coupled using the procedure of Example 17(b) to afford 0.23 g of the required product. Percentage purity (LCMS): 82.35%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722930B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-b2406b0beaed4f67ae878d506ffc2e92 |
| Source note | uspto-grants-2014_05 |