3-(Trifluoromethoxy)phenol → 6-(4-Cyanophenoxy)-5-fluoro-2-(3-trifluoromethoxyphenoxy)nicotinic acid ethyl ester

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Reaction Steps

2-chloro-6-(4-cyano phenoxy)-5-fluoro nicotinic acid ethyl ester (2.4 g, 7.49 mmol) and 3-trifluoromethoxyphenol (1.33 g, 7.49 mmol) were coupled using the procedure of Example 17(b) to afford 1.8 g of the required product. 1H NMR (DMSO-d6): δ 1.35 (3H, t), 4.4 (2H, q), 7.22 (2H, d), 7.3 (3H, d), 7.34 (1H, m), 7.54 (2H, d), 8.38 (1H, d).

Provenance & Evidence