4-Amino-1-Boc-piperidine → HCID 66818680, compound

HRID 1024720Notes

Reaction equation

HRID 1024720 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11]([OH:13])=O)=[CH:5][CH:4]=1)#[N:2].[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][CH:38]([NH:41][C:11](=[O:13])[C:10]2[CH:9]=[C:8]([O:7][C:6]3[CH:26]=[CH:27][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[CH:16]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:14]=2)[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 66818818HCID 66818818, compound

Product 1

HCID 66818680HCID 66818680, compoundYield 73.7%

Procedure

Following the procedure of Example 5(c) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 0.45 g (1.26 mmol) and 4-amino-piperidine-1-carboxylic acid tert-butyl ester (0.252 g, 1.26 mmol) were, used to afford 0.5 g of the required product. 1H NMR (DMSO-d6): δ 1.40 (9H, s), 1.75 (2H, m), 2.82 (2H, m), 3.18 (2H, d), 3.92 (3H, m), 7.25 (5H, m), 7.54 (2H, d), 7.88 (4H, d), 38 (1H, brs).

Sources & evidence

ORD record
ord-84f25aead4bf4138bf3d9dd3c3c1a2c3
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

Loading…