tert-Butyl piperazine-1-carboxylate → HCID 66818066, compound

HRID 1024723Notes

Reaction equation

HRID 1024723 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1)#[N:2].[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)=[O:34])(C)(C)[CH3:29]>>[CH2:28]([O:32][C:33]([N:35]1[CH2:36][CH2:37][N:38]([C:11](=[O:12])[C:10]2[CH:14]=[C:15]([O:17][C:18]3[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=3)[CH:16]=[C:8]([O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:27][CH:26]=3)[CH:9]=2)[CH2:39][CH2:40]1)=[O:34])[CH3:29]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 66818818HCID 66818818, compound

Product 1

HCID 66818066HCID 66818066, compoundYield 79.9%

Procedure

Following the procedure of Example 5(c) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 0.45 g (1.26 mmol) and piperazine-1-carboxylic acid tert-butyl ester (0.234 g, 1.26 mmol) were used to afford 0.5 g of the required product. 1H NMR (DMSO-d6): δ 1.18 (3H, t), 3.52 (8H, m), 4.15 (2H, q), 7.00 (2H, s), 7.07 (1H, s), 7.28 (2H, d), 7.88 (2H, d).

Sources & evidence

ORD record
ord-cdeaefe5e20245de9d04808d4a972393
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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