HCID 63990274, compound → HCID 66818799, compound

HRID 1024726Notes

Reaction equation

[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1)#[N:2].[C:28]([O:32][C:33](=[O:42])[NH:34][CH2:35][CH2:36][CH2:37][NH:38][CH:39]1[CH2:41][CH2:40]1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33](=[O:42])[NH:34][CH2:35][CH2:36][CH2:37][N:38]([C:11](=[O:12])[C:10]1[CH:9]=[C:8]([O:7][C:6]2[CH:26]=[CH:27][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:16]=[C:15]([O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=2)[CH:14]=1)[CH:39]1[CH2:41][CH2:40]1)([CH3:31])([CH3:29])[CH3:30]

Participants

Reactant 2

HCID 63990274HCID 63990274, compound

HCID 66818818HCID 66818818, compound

Product 1

HCID 66818799HCID 66818799, compoundYield 80.8%

Procedure

Following the procedure of Example 5(c) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 1.2 g (3.36 mmol) and (3-cyclopropylamino-propyl)-carbamic acid tert-butyl ester (0.72 g, 3.36 mmol) were used to afford 1.5 g of the required product. 1H NMR (DMSO-d6): δ 0.48 (1H, m), 0.65 (2H, m), 1.38 (9H, s), 1.42 (2H, m), 1.68 (2H, m), 2.95 (2H, m), 3.22 (2H, m), 6.80 (1H, brs), 6.95 (1H, s), 7.08 (2H, m), 7.25 (4H, m), 7.88 (4H, m).

Sources & evidence

ORD record: ord-4f82657801d14e30882c427f2cd6fb1e
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722930B2

Reaction notes

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