Cis tert-Butyl 4-aminocyclohexylcarbamate → HCID 66818473, compound

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Reaction Steps

Following the procedure of Example 5(c) 3-(4-(tert-butoxycarbonyl aminomethyl)benzyloxy)-5-(4-cyano phenoxy)benzoic acid 1.1 g (2.31 mmol) and (4-amino-cyclohexyl)-carbamic acid tert-butyl ester (0.494 g, 2.31 mmol) were used to afford 1.24 g of the required product. 1H NMR (DMSO-d6): δ 1.2 (4H, m), 1.4 (18H, s), 1.8 (4H, m), 3.2 (1H, m), 3.7 (1H, m), 4.1 (2H, d), 5.15 (2H, s), 6.74 (1H, d), 6.88 (1H, s), 7.12 (2H, d), 7.18 (1H, s), 7.26 (2H, d), 7.4 (4H, d), 7.86 (2H, d), 8.26 (1H, d).

Provenance & Evidence