N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → HCID 66818845, compound

Participants

Reaction Steps

3-tert-Butoxycarbonylamino-propionic acid (0.206 g, 1.09 mmol) and {4-[3-(3-amino benzyloxy)-5-(4-cyano phenoxy)benzoylamino]cyclohexyl}carbamic acid tert-butyl ester (0.6 g, 1.09 mmol) and other reagents as described in Example 9(e) were used to afford 0.45 g of the required product. 1H NMR (DMSO-d6): δ 1.25 (4H, m), 1.4 (18H, s), 1.8 (4H, m), 2.45 (2H, m), 3.1 (3H, m), 3.7 (2H, m), 5.15 (2H, s), 6.74 (1H, d), 6.88 (1H, m), 6.98 1H, s), 7.12 (3H, d), 7.2 (1H, s), 7.3 (1H, t), 7.42 (1H, s), 7.54 (1H, d), 7.72 (1H, s), 7.86 (2H, d), 8.26 (1H, d).

Provenance & Evidence