Ethyl 5-bromovalerate → HCID 66818833, compound

Participants

Reaction Steps

Using 0.63 g (1.39 mmol) of {4-[3-(4-cyanophenoxy)-5-hydroxybenzoylamino]cyclohexyl}carbamic acid tert-butyl ester and 5-bromo-pentanoic acid ethyl ester (0.29 g, 1.39 mmol) and following the procedure of Example 42(b) afforded 0.71 g of the required product. 1H NMR (DMSO-d6): δ 1.2 (4H, m), 1.25 (2H, m), 1.4 (9H, s), 1.75 (9H, m), 2.35 (2H, m) 3.2 (1H, m), 3.7 (1H, m), 4.05 (4H, m), 6.75 (1H, d), 6.9 (1H, s), 7.15 (3H, d), 7.35 (1H, s), 7.85 (2H, d), 8.25 (1H, d).

Provenance & Evidence