5-Chloro-2-nitropyridine → HCID 66818537, compound

Participants

Reaction Steps

Following the procedure of Example 69(b) {4-[3-(4-cyanophenoxy)-5-hydroxy-benzoylamino]cyclohexyl}carbamic acid tert-butyl ester 1.2 g (2.65 mmol) and 5-chloro-2-nitro-pyridine (0.84 g, 5.31 mmol) were used to afford 1.2 g of the required product. 1H NMR (DMSO-d6): δ 1.28 (3H, m), 1.4 (10H, s), 1.8 (5H, m), 3.20 (1H, m), 3.7 (1H, m), 6.75 (1H, d), 7.25 (2H, d), 7.35 (1H, d), 7.5 (2H, s), 7.8 (1H, dd), 7.9 (2H, d), 8.35 (2H, d), 8.5 (1H, s).

Provenance & Evidence