4-(Bromomethyl)benzonitrile → HCID 66818892, compound

Participants

Reaction Steps

[4-(2,4-Dihydroxy benzoylamino)cyclohexyl]carbamic acid tert-butyl ester (0.95 g, 2.71 mmol) and 4-bromomethyl-benzonitrile (2.12 g, 10.84 mmol) and other reagents as described in Example 75(a) were used to afford 1.2 g of the required product. 1H NMR (DMSO-d6): δ 1.20 (5H, m), 1.4 (9H, m), 1.75 (4H, m), 3.6 (1H, m), 5.3 (4H, s), 6.7 (1H, s), 6.85 (1H, s), 7.35 (2H, d), 7.5 (1H, s), 7.75 (4H, d), 7.9 (4H, s).

Provenance & Evidence