4-Aminocyclohexanol → HCID 66818612, compound

HRID 1024790Notes

Reaction equation

HRID 1024790 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11]([OH:13])=O)=[CH:5][CH:4]=1)#[N:2].[NH2:28][CH:29]1[CH2:34][CH2:33][CH:32]([OH:35])[CH2:31][CH2:30]1>>[C:24]([C:21]1[CH:22]=[CH:23][C:18]([O:17][C:15]2[CH:14]=[C:10]([CH:9]=[C:8]([O:7][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:27][CH:26]=3)[CH:16]=2)[C:11]([NH:28][CH:29]2[CH2:34][CH2:33][CH:32]([OH:35])[CH2:31][CH2:30]2)=[O:13])=[CH:19][CH:20]=1)#[N:25]

Participants

3

Reactant 2

HCID 812934-AminocyclohexanolHCID 66818818HCID 66818818, compound

Product 1

HCID 66818612HCID 66818612, compoundYield 39.4%

Procedure

Following the procedure of Example 9(e) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 0.1 g (0.28 mmol) and 4-amino-cyclohexanol (0.046 g, 0.42 mmol) were used to afford 0.05 g of the required product. Percentage purity (LCMS): 92.3%, (M+1)=453.1+1.

Sources & evidence

ORD record
ord-d8e301119c914411bea17ae6c67b2a3f
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

Loading…