HCID 66818704, compound → HCID 178453966, compound

HRID 1024805Notes

Reaction equation

HRID 1024805 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:18]([C:20]1[CH:34]=[CH:33][C:23]([O:24][C:25]2[CH:26]=[C:27]([NH2:32])[CH:28]=[C:29]([OH:31])[CH:30]=2)=[CH:22][CH:21]=1)#[N:19]>>[C:1]([O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15](=[O:17])[NH:32][C:27]2[CH:28]=[C:29]([OH:31])[CH:30]=[C:25]([O:24][C:23]3[CH:22]=[CH:21][C:20]([C:18]#[N:19])=[CH:34][CH:33]=3)[CH:26]=2)[CH2:13][CH2:14]1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 66818704HCID 66818704, compoundHCID 178453972HCID 178453972, compound

Product 1

HCID 178453966HCID 178453966, compoundYield 74.8%

Procedure

Following the procedure of Example 9(e) Trans-4-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 0.72 g (2.96 mmol) and [3-(4-cyano-phenoxy)-5-hydroxy-phenyl]-amine (0.67 g, 2.96 mmol) were used to afford 1.0 g of the required product. Percentage purity (LCMS): 73.5%, (M+1)=451.5+1.

Sources & evidence

ORD record
ord-512b18cec7254347885405ab980385e2
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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