Ammonium Chloride → HCID 178453964, compound

Participants

Reaction Conditions

Reaction Steps

{Trans-4-[3-(3-amino-4-nitro-phenoxy)-5-(4-cyano-phenoxy)-phenyl-carbamoyl}-cyclohexyl]-carbamic acid tert-butyl ester (1.0 g, 1.7 mmol), zinc (1.11 g, 17.02 mmol) and ammoniumchloride (0.91 g, 17.02 mmol) were dissolved in 20 ml of methanol and stirred for 2 h at 60° C. After reaction completion contents were filtered through celite and filetrate was concentrated to afford 0.8 g of the required product. 1H NMR (DMSO-d6): δ 1.45 (9H, s), 1.78 (4H, m), 2.45 (4H, m), 3.2 (1H, m), 4.42 (2H, s), 6.45 (2H, m), 6.5 (1H, d), 6.71 (2H, m), 7.15 (2H, d), 7.3 (2H, s), 7.8 (2H, d), 8.28 (1H, d).

Provenance & Evidence