HCID 66818705, compound → HCID 66819115, compound

HRID 1024808Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:18]([C:20]1[CH:44]=[CH:43][C:23]([CH2:24][O:25][C:26]2[CH:27]=[C:28]([NH2:42])[CH:29]=[C:30]([O:32][CH2:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]#[N:41])=[CH:36][CH:35]=3)[CH:31]=2)=[CH:22][CH:21]=1)#[N:19]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][CH2:11][CH:12]([C:15](=[O:17])[NH:42][C:28]2[CH:29]=[C:30]([O:32][CH2:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]#[N:41])=[CH:36][CH:35]=3)[CH:31]=[C:26]([O:25][CH2:24][C:23]3[CH:22]=[CH:21][C:20]([C:18]#[N:19])=[CH:44][CH:43]=3)[CH:27]=2)[CH2:13][CH2:14]1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 66818705HCID 66818705, compound

HCID 178453972HCID 178453972, compound

Product 1

HCID 66819115HCID 66819115, compoundYield 64.6%

Procedure

Following the procedure of Example 107(e) trans-4-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 0.255 g (1.04 mmol) and [3,5-Bis-(4-cyano-benzyloxy)-phenyl]-amine (0.37 g, 1.04 mmol) were used to afford 0.39 g of the required product. Percentage purity (LCMS): 94.8%, (M−1)=580.0-1.

Sources & evidence

ORD record: ord-78c28a2949904c7b9e21dc7d63199501
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722930B2

Reaction notes

Loading…