HCID 67606116, compound → HCID 66818556, compound

HRID 1024810Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:18]([C:20]1[CH:21]=[C:22]([CH:42]=[CH:43][CH:44]=1)[CH2:23][O:24][C:25]1[CH:26]=[C:27]([NH2:41])[CH:28]=[C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=2)[CH:30]=1)#[N:19]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][CH2:11][CH:12]([C:15](=[O:17])[NH:41][C:27]2[CH:28]=[C:29]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[C:35]([C:39]#[N:40])[CH:34]=3)[CH:30]=[C:25]([O:24][CH2:23][C:22]3[CH:42]=[CH:43][CH:44]=[C:20]([C:18]#[N:19])[CH:21]=3)[CH:26]=2)[CH2:13][CH2:14]1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 67606116HCID 67606116, compound

HCID 178453972HCID 178453972, compound

Product 1

HCID 66818556HCID 66818556, compoundYield 62.5%

Procedure

Following the procedure of Example 107(e) trans-4-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 0.41 g (1.68 mmol) and [3,5-Bis-(3-cyano-benzyloxy)-phenyl]-amine (0.6 g, 1.68 mmol) were used to afford 0.61 g of the required product. Percentage purity (LCMS): 79.8%, (M−1)=580.0-1.

Sources & evidence

ORD record: ord-0a604461d16142a9a9720538162607fc
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722930B2

Reaction notes

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