[3,5-Bis-(4-cyano-phenoxy)-phenyl]-amine → HCID 178461283, compound

HRID 1024811Notes

Reaction equation

HRID 1024811 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.[C:11]([C:13]1[CH:35]=[CH:34][C:16]([O:17][C:18]2[CH:19]=[C:20]([NH2:33])[CH:21]=[C:22]([O:24][C:25]3[CH:30]=[CH:29][C:28]([C:31]#[N:32])=[CH:27][CH:26]=3)[CH:23]=2)=[CH:15][CH:14]=1)#[N:12]>>[C:31]([C:28]1[CH:29]=[CH:30][C:25]([O:24][C:22]2[CH:21]=[C:20]([NH:33][C:8]([C@H:5]3[CH2:4][CH2:3][C@H:2]([CH3:1])[CH2:7][CH2:6]3)=[O:10])[CH:19]=[C:18]([O:17][C:16]3[CH:34]=[CH:35][C:13]([C:11]#[N:12])=[CH:14][CH:15]=3)[CH:23]=2)=[CH:26][CH:27]=1)#[N:32]

Participants

3

Reactant 2

HCID 66818846[3,5-Bis-(4-cyano-phenoxy)-phenyl]-amineHCID 178461286HCID 178461286, compound

Product 1

HCID 178461283HCID 178461283, compoundYield 94.7%

Procedure

Following the procedure of Example 107(e) trans-4-methyl-cyclohexanecarboxylic acid 0.21 g (1.52 mmol) and [3,5-bis-(4-cyano-phenoxy)-phenyl]-amine (0.50 g, 1.52 mmol) were used to afford 0.65 g of the required product. Percentage purity (LCMS): 85.4%, (M+1)=451.1+1.

Sources & evidence

ORD record
ord-fccc693cade2439db9aa6e615c976233
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

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