Cyclohexylamine → HCID 66818512, compound

HRID 1024816Notes

Reaction equation

HRID 1024816 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11]([OH:13])=O)=[CH:5][CH:4]=1)#[N:2].[CH:28]1([NH2:34])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11]([NH:34][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:13])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 66818818HCID 66818818, compound

Product 1

HCID 66818512HCID 66818512, compoundYield 99.6%

Procedure

Following the procedure of Example 9(e) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 0.5 g (1.4 mmol) and cyclohexylamine (0.14 g, 1.4 mmol) were used to afford 0.61 g of the required product. Percentage purity (LCMS): 78.1%, (M+1)=437.0+1.

Sources & evidence

ORD record
ord-212ec775a01f4b48bd77d979d14d72a1
Source dataset
uspto-grants-2014_05
Patent number
US08722930B2

Reaction notes

Loading…