4-Methylcyclohexylamine → HCID 66818328, compound

HRID 1024818Notes

Reaction equation

[C:1]([C:3]1[CH:27]=[CH:26][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=3)[CH:16]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1)#[N:2].[CH3:28][CH:29]1[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[CH:9]=[C:10]([CH:14]=[C:15]([O:17][C:18]3[CH:19]=[CH:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=3)[CH:16]=2)[C:11]([NH:35][CH:32]2[CH2:33][CH2:34][CH:29]([CH3:28])[CH2:30][CH2:31]2)=[O:12])=[CH:26][CH:27]=1)#[N:2]

Participants

Reactant 2

HCID 806044-Methylcyclohexylamine

HCID 66818818HCID 66818818, compound

Product 1

HCID 66818328HCID 66818328, compoundYield 105.5%

Procedure

Following the procedure of Example 9(e) 3,5-bis-(4-cyano-phenoxy)-benzoic acid 0.5 g (1.26 mmol) and 4-methylcyclohexylamine (0.143 g, 1.26 mmol) were used to afford 0.6 g of the required product. Percentage purity (LCMS): 84.6%, (M+1)=451.1+1.

Sources & evidence

ORD record: ord-5dbcdc8d4c8b49428b3b3ce4dd6589f3
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722930B2

Reaction notes

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