HRID1024918

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)Oc1cc(Cl)nc(SCc2cccc(F)c2F)n1

HCID53628345

未命名化合物

HCID53628365

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@H](COC(c1ccccc1)(c1ccccc1)c1ccccc1)Oc1cc(NS(=O)(=O)c2ccc(C(=O)N3CCC3)o2)nc(SCc2cccc(F)c2F)n1

HCID53628364

未命名化合物

PROCEDURE

实验过程

The subtitle compound was prepared from 5-(azetidin-1-ylcarbonyl)furan-2-sulfonamide (the product of step iii) (0.40 g) and 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R)-1-methyl-2-(triphenylmethoxy)ethoxy]-pyrimidine (the product of Example 13, step iii) (0.41 g) according to the procedure outlined in Example 1, step iv). Yield: 0.25 g

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3a1f26254704b0b8e84f0c5613af39d
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08722883B2
来源说明: uspto-grants-2014_05

反应 SMILES

[N:1]1([C:5]([C:7]2[O:11][C:10]([S:12]([NH2:15])(=[O:14])=[O:13])=[CH:9][CH:8]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1.Cl[C:17]1[CH:22]=[C:21]([O:23][C@H:24]([CH3:46])[CH2:25][O:26][C:27]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:20]=[C:19]([S:47][CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[C:50]=2[F:56])[N:18]=1>>[N:1]1([C:5]([C:7]2[O:11][C:10]([S:12]([NH:15][C:17]3[CH:22]=[C:21]([O:23][C@H:24]([CH3:46])[CH2:25][O:26][C:27]([C:40]4[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=4)([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[N:20]=[C:19]([S:47][CH2:48][C:49]4[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[C:50]=4[F:56])[N:18]=3)(=[O:14])=[O:13])=[CH:9][CH:8]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1