Sodium Hydroxide → HCID 86691762, compound

HRID 1024979Notes

Reaction equation

HRID 1024979 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:38])[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([S:14](=[O:37])(=[O:36])[NH:15][C:16]2[CH:21]=[C:20]([O:22][CH3:23])[N:19]=[C:18]([S:24]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=3[F:35])(=[O:26])=[O:25])[N:17]=2)[CH2:10][CH2:9]1)C>CO>[F:35][C:29]1[C:30]([F:34])=[CH:31][CH:32]=[CH:33][C:28]=1[CH2:27][S:24]([C:18]1[N:17]=[C:16]([NH:15][S:14]([N:11]2[CH2:10][CH2:9][N:8]([CH2:7][C:6]([OH:38])=[O:5])[CH2:13][CH2:12]2)(=[O:36])=[O:37])[CH:21]=[C:20]([O:22][CH3:23])[N:19]=1)(=[O:25])=[O:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86691763HCID 86691763, compound

Product 1

HCID 86691762HCID 86691762, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by adding 1M NaOH (1 mL) to a solution of {4-[2-(2,3-Difluoro-benzylsulfonyl)-6-methoxy-pyrimidin-4-ylsulfamoyl]-piperazin-1-yl}-acetic acid ethyl ester (the product from step i) (0.31 g) in MeOH (1 mL). Purification was by reverse phase HPLC (symmetry as the stationary phase and TFA/acetonitrile as the mobile phase) then titurated with Toluene, DCM followed by Et2O to give the title compound as a white solid. Yield: 85 mg

Workup

  1. customThe title compound was prepared
  2. customPurification

Sources & evidence

ORD record
ord-c14d1d1d991e4e09a86cde8b994f6048
Source dataset
uspto-grants-2014_05
Patent number
US08722883B2

Reaction notes

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