HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Chloro-2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4,6-Dichloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidine | HCID 85928017 | — |
| Product | 4-Chloro-2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidine | HCID 86619889 | — |
Reaction Steps
The subtitle compound was prepared according to the procedure outlined in example 35 Step (i) using 4,6-dichloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidine (prepared according to patent WO 2004/011443) (0.65 g), methanol (8 mL) and 60% sodium hydride (88 mg). Yield: 0.57 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722883B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-64a783b5378e48758533de2e02010ac4 |
| Source note | uspto-grants-2014_05 |