HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (1-Pyrimidin-4-yl-cyclopropyl)-carbamic acid tert-butyl ester | HCID 67292536 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride | HCID 67292441 | — |
Reaction Steps
A solution of tert-butyl 1-(pyrimidin-4-yl)cyclopropylcarbamate (0.100 g, 0.425 mmol, 1.0 eq), in 4.0 M HCl in 1,4-dioxane (4.0 ml) was stirred at r.t. for 5 hr. The reaction mixture was concentrated completely and the HCl salt was taken to next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722688B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-16cc59ecc25343ceab77223f44ab138a |
| Source note | uspto-grants-2014_05 |