Pyridine → HCID 86762401, compound

Participants

Reaction Conditions

Reaction Steps

Cysteamine hydrochloride (1 g, 8.8 mM) was dissolved in dichloromethane (DCM, 6 mL) containing pyridine (3 mL) and the solution cooled (−10° C.). A solution of allyl chloroformate (2 mL, 18.86 mM) in DCM (3 mL) was dropwise added into the stirred cold cysteamine solution. Following the addition, reaction temperature was allowed to rise to room temperature (22° C.), when tlc (Hexane-Ethyl acetate, 2:1; 6:1 v/v) indicated product. Methanol (2 mL) was added followed by CHCl3 (10 mL), stirring continued for 2 h following which the reaction mixture was transferred into a separating funnel and washed (general method). Organic layer was dried (MgSO4), filtered, evaporated under vacuum to a syrup and column chromatographed (prepacked silica, 40 g) using hexane-ethyl acetate (12:1 v/v) to give the name compound (1.6 g).

Provenance & Evidence