反应详情

100 g of ethyl 2,2-difluoro-3-(methacryloyloxy)pentanoate was dissolved in 1000 g of dehydrated methanol in a nitrogen atmosphere. After the addition of 0.1 g of N,N-dimethylaminopyridine (DMAP), the mixture was heated and refluxed for 5 hours. After evaporating the solvent, the residue was dissolved in 1000 g of dehydrated methanol, and the mixture was heated and refluxed for 5 hours. After evaporating the solvent, the residue was dissolved in 300 g of n-hexane. The solution was filtered through 50 g of silica gel to remove DMAP. 89.7 g of methyl 2,2-difluoro-3-(methacryloyloxy)pentanoate (M-29) was thus obtained (yield: 95%).

1. temperaturethe mixture was heated
2. temperaturerefluxed for 5 hours
3. customAfter evaporating the solvent
4. dissolutionthe residue was dissolved in 1000 g of dehydrated methanol
5. temperaturethe mixture was heated
6. temperaturerefluxed for 5 hours
7. customAfter evaporating the solvent
8. dissolutionthe residue was dissolved in 300 g of n-hexane
9. filtrationThe solution was filtered through 50 g of silica gel
10. customto remove DMAP