HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 5-(Ethoxymethyl)picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | HCID 46901655 | HCID 46901655 | — |
| Product | 5-(Ethoxymethyl)picolinonitrile | HCID 67086060 | — |
Reaction Steps
(6-Cyanopyridin-3-yl)methyl methanesulfonate (199 mg, 0.94 mmol) in 2 mL anhydrous EtOH was heated at 85° C. in a sealed tube for 3.5 h. The mixture was concentrated and purified by silica gel chromatography (elution with 0-25% EtOAc/Hex) to afford 5-(ethoxymethyl)picolinonitrile (104 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729071B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-0f2b3ec2ac424c3a9666747ef33c3896 |
| Source note | uspto-grants-2014_05 |