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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1025306Generated: October 26, 2026

(S)-(-)-2-(tert-Butoxycarbonylamino)-3-cyclohexyl-1-propanol → (2S,3S)-3-Amino-4-cyclohexyl-N-cyclopropyl-2-hydroxybutanamide dihydrochloride

https://huagongshe.com/reaction/1025306

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-(-)-2-(tert-Butoxycarbonylamino)-3-cyclohexyl-1-propanolHCID 11043405—
Reactant(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochlorideHCID 86762404—
Product(2S,3S)-3-Amino-4-cyclohexyl-N-cyclopropyl-2-hydroxybutanamide dihydrochlorideHCID 86762409—

Reaction Steps

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, starting with (S)-tert-butyl 1-cyclohexyl-3-hydroxypropan-2-ylcarbamate in the second step (A2).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729061B2
Source datasetuspto-grants-2014_05
ORD IDord-cff7caca12fd44209ceacd655affce20
Source noteuspto-grants-2014_05