1,1-Dimethylethyl N-((1S)-2-hydroxy-1-methylethyl)carbamate → HCID 86762415, compound

HRID 1025309Notes

Reaction equation

HRID 1025309 reaction equation
[ClH:1].Cl.[NH2:3][C@@H:4]([CH2:13]C)[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1[CH2:11][CH2:10]1)=[O:7].OC[C@@H](NC(=O)OC(C)(C)C)C>>[ClH:1].[ClH:1].[NH2:3][C@@H:4]([CH3:13])[C@H:5]([OH:12])[C:6]([NH:8][CH:9]1[CH2:10][CH2:11]1)=[O:7]

Participants

3

Reactant 2

HCID 70231031,1-Dimethylethyl N-((1S)-2-hydroxy-1-methylethyl)carbamateHCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

Product 1

HCID 86762415HCID 86762415, compound

Procedure

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, starting with (S)-tert-butyl 1-hydroxypropan-2-ylcarbamate in the second step (A2).

Sources & evidence

ORD record
ord-2200b12774724af8b889f5349e454331
Source dataset
uspto-grants-2014_05
Patent number
US08729061B2

Reaction notes

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