HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanamine, 2,2,2-trifluoro- → (2S,3S)-3-Amino-2-hydroxy-N-(2,2,2-trifluoroethyl)hexanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| Reactant | L-Norvaline | HCID 65098 | — |
| Reactant | (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide | HCID 57872123 | — |
| Product | (2S,3S)-3-Amino-2-hydroxy-N-(2,2,2-trifluoroethyl)hexanamide | HCID 86762421 | — |
Reaction Steps
The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide, Representative Procedure B, using (S)-2-aminopentanoic acid in the first step (step B1), and 2,2,2-trifluoro-ethylamine in the seventh step (step B7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729061B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-bbd88f2bfdc04cbe827c3819a7a18584 |
| Source note | uspto-grants-2014_05 |