2-(Naphthalen-2-yl)ethan-1-amine hydrochloride → (2S,3S)-3-Amino-2-hydroxy-N-(2-(naphthalen-2-yl)ethyl)pentanamide

HRID 1025319Notes

Reaction equation

HRID 1025319 reaction equation
[NH2:1][C@@H:2]([CH2:11][CH3:12])[C@H:3]([OH:10])[C:4](NC1CC1)=[O:5].Cl.[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[CH2:24][CH2:25][NH2:26]>>[NH2:1][C@@H:2]([CH2:11][CH3:12])[C@H:3]([OH:10])[C:4]([NH:26][CH2:25][CH2:24][C:15]1[CH:16]=[CH:17][C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:14]=1)=[O:5]

Participants

3

Reactant 2

HCID 162181222-(Naphthalen-2-yl)ethan-1-amine hydrochlorideHCID 57872123(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide

Product 1

HCID 86762430(2S,3S)-3-Amino-2-hydroxy-N-(2-(naphthalen-2-yl)ethyl)pentanamide

Procedure

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide, Representative Procedure B, using 2-(naphthalen-2-yl)ethanamine hydrochloride in the seventh step (step B7).

Sources & evidence

ORD record
ord-92a229db2a494df99a34f9186416b729
Source dataset
uspto-grants-2014_05
Patent number
US08729061B2

Reaction notes

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