Hydrochloric Acid → (2S)-2-amino-1-(benzo[d]oxazol-2-yl)butan-1-ol dihydrochloride

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Reaction Steps

Under an atmosphere of argon, tert-butyl (2S)-1-(benzo[d]oxazol-2-yl)-1-hydroxybutan-2-ylcarbamate (800 mg, 2.61 mmol, Eq: 1.00) and HCl 4M in dioxane (17.3 ml) were combined to give a dark brown solution. The reaction was stirred for 2 h at RT. The crude reaction mixture was concentrated in vacuo, and the residual solvent was removed under vacuum. The title compound was obtained as a dark brown gum (910 mg, quant., MS (m/e)=207.1 [M+H+]).

Provenance & Evidence