HCID 86762436, compound → HCID 86762437, compound

HRID 1025331Notes

Reaction equation

HRID 1025331 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[S:14]([C@H:17]1[CH2:21][N:20]([C:22]([O:24]C(C)(C)C)=O)[C@H:19]([C:29]([O:31]C)=[O:30])[CH2:18]1)(=[O:16])=[O:15].[Cl:33][C:34]1[CH:35]=[C:36]([F:46])[C:37]([C:40]2(C(O)=O)[CH2:42][CH2:41]2)=[N:38][CH:39]=1>>[Cl:33][C:34]1[CH:35]=[C:36]([F:46])[C:37]([C:40]2([C:22]([N:20]3[CH2:21][C@H:17]([S:14]([C:3]4[CH:4]=[CH:5][C:6]([O:8][CH2:9][C:10]([F:13])([F:11])[F:12])=[CH:7][C:2]=4[Cl:1])(=[O:16])=[O:15])[CH2:18][C@H:19]3[C:29]([OH:31])=[O:30])=[O:24])[CH2:41][CH2:42]2)=[N:38][CH:39]=1

Participants

3

Reactant 2

HCID 86762436HCID 86762436, compoundHCID 86762438HCID 86762438, compound

Product 1

HCID 86762437HCID 86762437, compound

Procedure

The title compound was prepared in analogy to General Procedure C, steps C4-C6, using (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-(2,2,2-trifluoroethoxy)phenylsulfonyl)pyrrolidine-1,2-dicarboxylate in step C4, and 1-(5-chloro-3-fluoro-pyridin-2-yl)-cyclopropanecarboxylic acid in step C5. MS (m/e)=584.9 [M+H+].

Sources & evidence

ORD record
ord-bcb99b4ba3134e50bcfae8a087ac4346
Source dataset
uspto-grants-2014_05
Patent number
US08729061B2

Reaction notes

Loading…