HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-1-(2-nitrophenyl)-4-(2-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylic acid → (2S,4R)-1-(2-Nitro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazole-2-carbonyl)-propyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-1-(2-nitrophenyl)-4-(2-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylic acid | HCID 66770587 | — |
| Reactant | (2S)-2-amino-1-(benzo[d]oxazol-2-yl)butan-1-ol dihydrochloride | HCID 86762432 | — |
| Product | (2S,4R)-1-(2-Nitro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazole-2-carbonyl)-propyl]-amide | HCID 71577052 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, using (2S,4R)-1-(2-nitrophenyl)-4-(2-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylic acid (prepared as described in U.S. Pat. Appl. US20100267722) and (2S)-2-amino-1-(benzo[d]oxazol-2-yl)butan-1-ol dihydrochloride in step 1. MS (m/e)=631.15 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729061B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-72a09f9d86dc460f81f926a20f1b6833 |
| Source note | uspto-grants-2014_05 |