HRID1025340

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16739337

(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide

C9H18N2O2

结构：O=C(O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1

HCID86762443

未命名化合物

PRODUCTS

生成物

结构：CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1C(=O)C1(c2ncc(Cl)cc2F)CC1)C(=O)C(=O)NC1CC1

HCID71577391

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 1, using (2S,4R)-1-[1-(5-chloro-3-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid and (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide in step 1. MS (m/e)=687.17 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e6fd4dc33ae34a99bd62ab23205ed637
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729061B2
来源说明: uspto-grants-2014_05

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([F:34])[C:5]([C:8]2([C:11]([N:13]3[CH2:17][C@H:16]([S:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([F:30])([F:29])[F:28])(=[O:20])=[O:19])[CH2:15][C@H:14]3[C:31](O)=[O:32])=[O:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[NH2:35][C@@H:36]([CH2:45][CH2:46][CH3:47])[C@H:37]([OH:44])[C:38]([NH:40][CH:41]1[CH2:43][CH2:42]1)=[O:39]>>[Cl:1][C:2]1[CH:3]=[C:4]([F:34])[C:5]([C:8]2([C:11]([N:13]3[CH2:17][C@H:16]([S:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[C:27]([F:30])([F:29])[F:28])(=[O:19])=[O:20])[CH2:15][C@H:14]3[C:31]([NH:35][C@@H:36]([CH2:45][CH2:46][CH3:47])[C:37](=[O:44])[C:38]([NH:40][CH:41]3[CH2:43][CH2:42]3)=[O:39])=[O:32])=[O:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1