HRID1025344

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16739337

(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide

C9H18N2O2

反应SMILES：C[C@H](Oc1ccc(S(=O)(=O)[C@@H]2C[C@@H](C(=O)O)N(C(=O)C3(c4ccc(Cl)cc4)CC3)C2)c(Cl)c1)C(F)(F)F

HCID86762445

未命名化合物

PRODUCTS

产物

反应SMILES：CCC[C@H](NC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(O[C@@H](C)C(F)(F)F)cc2Cl)CN1C(=O)C1(c2ccc(Cl)cc2)CC1)C(=O)C(=O)NC1CC1

HCID71576892

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 1, using (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide and (2S,4R)-1-[1-(4-chloro-phenyl)-cyclopropanecarbonyl]-4-[2-chloro-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-pyrrolidine-2-carboxylic acid in step 1. MS (m/e)=746.17 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-1328aa9a6e274e24a1a18d129b498ece
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08729061B2
来源说明: uspto-grants-2014_05

反应SMILES

[NH2:1][C@@H:2]([CH2:11][CH2:12][CH3:13])[C@H:3]([OH:10])[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2([C:24]([N:26]3[CH2:30][C@H:29]([S:31]([C:34]4[CH:39]=[CH:38][C:37]([O:40][C@@H:41]([CH3:46])[C:42]([F:45])([F:44])[F:43])=[CH:36][C:35]=4[Cl:47])(=[O:33])=[O:32])[CH2:28][C@H:27]3[C:48](O)=[O:49])=[O:25])[CH2:23][CH2:22]2)=[CH:17][CH:16]=1>>[Cl:47][C:35]1[CH:36]=[C:37]([O:40][C@@H:41]([CH3:46])[C:42]([F:45])([F:44])[F:43])[CH:38]=[CH:39][C:34]=1[S:31]([C@H:29]1[CH2:30][N:26]([C:24]([C:21]2([C:18]3[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=3)[CH2:22][CH2:23]2)=[O:25])[C@H:27]([C:48]([NH:1][C@@H:2]([CH2:11][CH2:12][CH3:13])[C:3](=[O:10])[C:4]([NH:6][CH:7]2[CH2:8][CH2:9]2)=[O:5])=[O:49])[CH2:28]1)(=[O:32])=[O:33]