HCID 86762447, compound → HCID 71578055, compound

HRID 1025347Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][C:3]=1[S:14]([C@H:17]1[CH2:21][N:20]([C:22]([C:24]2([C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)[CH2:26][CH2:25]2)=[O:23])[C@H:19]([C:34](O)=[O:35])[CH2:18]1)(=[O:16])=[O:15].[CH:37]1([NH:40][C:41](=[O:48])[C:42](=[O:47])[C@@H:43]([NH2:46])[CH2:44][CH3:45])[CH2:39][CH2:38]1>>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH:5]=[CH:4][C:3]=1[S:14]([C@H:17]1[CH2:21][N:20]([C:22]([C:24]2([C:27]3[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=3)[CH2:26][CH2:25]2)=[O:23])[C@H:19]([C:34]([NH:46][C@@H:43]([CH2:44][CH3:45])[C:42](=[O:47])[C:41]([NH:40][CH:37]2[CH2:39][CH2:38]2)=[O:48])=[O:35])[CH2:18]1)(=[O:15])=[O:16]

Participants

Reactant 2

HCID 86762447HCID 86762447, compound

HCID 86762448HCID 86762448, compound

Product 1

HCID 71578055HCID 71578055, compound

Procedure

The title compound was prepared in analogy to Example 1, using (2S,4R)-4-(2-Chloro-4-morpholin-4-yl-benzenesulfonyl)-1-[1-(4-chloro-phenyl)-cyclopropane carbonyl]-pyrrolidine-2-carboxylic acid and (S)-3-Amino-2-oxo-pentanoic acid cyclopropylamide in step 1. MS (m/e)=705.19 [M+H+].

Sources & evidence

ORD record: ord-0443d10082484c79998db0f556f948aa
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729061B2

Reaction notes

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