HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4R)-4-(2-chloro-benzenesulfonyl)-1-[1-(5-chloro-3-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-pyrrolidine-2-carboxylic acid → (2S,4R)-N-((S)-1-(butylamino)-1,2-dioxopentan-3-yl)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chlorophenylsulfonyl)pyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-[1-(5-chloro-3-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-pyrrolidine-2-carboxylic acid | HCID 86762444 | — |
| Reactant | (S)-3-Amino-2-oxo-pentanoic acid butylamide | HCID 86762451 | — |
| Product | (2S,4R)-N-((S)-1-(butylamino)-1,2-dioxopentan-3-yl)-1-(1-(5-chloro-3-fluoropyridin-2-yl)cyclopropanecarbonyl)-4-(2-chlorophenylsulfonyl)pyrrolidine-2-carboxamide | HCID 71577972 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, using (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[1-(5-chloro-3-fluoro-pyridin-2-yl)-cyclopropanecarbonyl]-pyrrolidine-2-carboxylic acid and (S)-3-Amino-2-oxo-pentanoic acid butylamide in step 1. MS (m/e)=655.15 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729061B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f5f081176804408e92691f65fd6c301d |
| Source note | uspto-grants-2014_05 |