HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-(Azepan-1-yl)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2-(3-(Azepan-1-yl)propyl)isoindoline-1,3-dione | HCID 58540561 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Azepan-1-yl)propan-1-amine | HCID 2764395 | — |
Reaction Steps
To a solution of 2-(3-(azepan-1-yl)propyl)isoindoline-1,3-dione (3.5 g) in Ethanol (20 mL) was added hydrazine (0.58 mL). The reaction mixture was reflux for 13 h and then cooled down to room temperature. TFA (2.0 mL) was added, the resulted white solid was filtered and the solvent was evaporated to give 3-(azepan-1-yl)propan-1-amine, used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729081B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-a96ef221609240c7a545a00ae414c4b8 |
| Source note | uspto-grants-2014_05 |