HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Chloro-6,7-dimethyl-quinoxalin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 2,3-Dichloro-6,7-dimethylquinoxaline | HCID 4092647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Chloro-6,7-dimethyl-quinoxalin-2-ylamine | HCID 85659213 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2,3-dichloro-6,7-dimethyl-quinoxaline (30 g) in 300 mL of THF was cooled with dry-ice in a sealed vessel. Ammonia gas was added for 10 min, then the mixture was heated to 100° C. for 20 h. After removal of the solvent in vaccuo the residue was purified by flash chromatography to yield 14 g of the title compound. 1H-NMR (300 MHz, d6-DMSO): δ=7.43 (1H, s), 7.37 (1H, s), 7.00 (2H, s), 2.28 (6H, s) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729082B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ac1cc7516bbc4f06a12ba5cae3ed3853 |
| Source note | uspto-grants-2014_05 |