Hydrochloric Acid → 4-(7-Fluoro-2,3-dihydrobenzofuran-2-yl)piperidin-4-ol hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-(7-fluoro-2,3-dihydrobenzofuran-2-yl)-4-hydroxypiperidine-1-carboxylate (0.404 g, 1.197 mmol) in MeOH (7.04 mL) was added HCl in dioxane (4 M, 4.4 mL, 17.48 mmol). Upon completion of addition, the reaction mixture was stirred at room temperature for 5 hours. After this time, the solvent was removed under reduced pressure to afford Compound 1F as a light yellow solid (0.38 g, 100% yield). LC/MS (m/z)=238 (M+H)+.

Provenance & Evidence