tert-Butyl 4-(7-fluorobenzofuran-2-yl)piperidine-1-carboxylate → tert-Butyl 4-(7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylate

Participants

Reaction Steps

To a degassed solution of tert-butyl 4-(7-fluorobenzofuran-2-yl)piperidine-1-carboxylate (3.4 g, 8.41 mmol) in EtOH (54.3 mL) was added 10% Pd—C (2.69 g, 2.52 mmol). Upon completion of addition, the reaction mixture was charged with 55 psi of H2 overnight. At the conclusion of this period, the Pd—C was filtered off through a pad of CELITE®, and the filter cake was rinsed with EtOH. The filtrate was concentrated under reduced pressure to afford Compound 3C as a colorless oil (2.36 g, 87% yield), which was used in next step without further purification. LC/MS (m/z)=344 (M+Na)+.

Provenance & Evidence